Association of Cadmium, Chromium, Manganese and Lead with Hyperprolactinemia: A Pilot Study
Published: January 1, 2020 | DOI: https://doi.org/10.7860/JCDR/2020/42690.13439
Amanpreet Kaur Kalsi, Ashutosh Halder, Manish Jain, Amita Srivastava
1. PhD Student, Department of Reproductive Biology, All India Institute of Medical Sciences, New Delhi, India.
2. Professor and Head, Department of Reproductive Biology, All India Institute of Medical Sciences, New Delhi, India.
3. Scientist, Department of Reproductive Biology, All India Institute of Medical Sciences, New Delhi, India.
4. Scientist, Department of Pharmacology, All India Institute of Medical Sciences, New Delhi, India.
Correspondence
Dr. Amanpreet Kaur Kalsi,
2083, Department of Reproductive Biology, II Floor, Teaching Block, All India Institute of Medical Sciences, Ansari Nagar, New Delhi-110029, India.
E-mail: kalsi.amanpreetkaur@gmail.com
Introduction: Hyperprolactinemia is one of the most common hypothalamic-pituitary dysfunctions where serum prolactin levels increase beyond normal range. Studies have suggested association of heavy metals with prolactin levels.
Aim: To investigate the association of serum levels of heavy metals with prolactin levels in hyperprolactinemia patients.
Materials and Methods: A total of 102 hyperprolactinemia patients (>100 ng/mL serum prolactin levels) and 25 controls were included in the study. Hyperprolactinemia patients were classified into macroprolactinemia (n=22) and true hyperprolactinemia (n=80) based on post Poly Ethylene Glycol (PEG) recovery of prolactin of <25%. Serum Cadmium (Cd), Chromium (Cr), Manganese (Mn) and Lead (Pb) levels were analysed using Inductively Coupled Plasma Atomic Emission Spectrometry (ICP-AES) method. Statistical analysis was done using SPSS version 21.0 and Stata version 14.2. Student's t-test and Pearson correlation were used. The p<0.05 was considered statistically significant.
Results: There was no significant correlation between serum levels of prolactin and heavy metals Cd (r=0.067, p=0.457), Cr (r=-0.065, p=0.465), Mn (r=-0.076, p=0.393) and Pb (r=-0.148, p=0.097). No significant difference was found in serum levels of heavy metals between macroprolactinemia and true hyperprolactinemia patients (p=0.521, 0.690, 0.564 and 0.488 for Cd, Cr, Mn and Pb, respectively). ROC analysis also did not reveal any significance in any of the four heavy metals studied.
Conclusion: The results suggest that probably there is no association of serum prolactin levels, macroprolactinemia or hyperprolactinemia with heavy metals.
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